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phenobarbital will lessen the extent or effect of rabeprazole by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Unknown.phenobarbital decreases levels of vandetanib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Stay away from coadministration with potent CYP3A4 inducers; these medications le